7tuq

X-ray diffraction
2.68Å resolution

Crystal structure of BRD4 bromodomain 1 in complex with monoacetylated SARS-CoV-2 E

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
PDBe Complex ID:
PDB-CPX-130115 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 140 amino acids
Theoretical weight: 16.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 42-180; Coverage: 10%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Envelope small membrane protein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Not provided
UniProt:
  • Canonical: P0DTC4 (Residues: 60-68; Coverage: 12%)
Gene names: 4, E

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 78.463Å b: 91.392Å c: 100.268Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.216 0.276
Expression systems:
  • Escherichia coli
  • Not provided