› 7t7c

Electron Microscopy
10Å resolution

The hexagonal organization of Munc13-1 C1-C2B-MUN-C2C domains between lipid bilayers

Released:
DOI: 10.2210/pdb7t7c/pdb
PDB entry 7t7c coloured by chain, front view.
PDB entry 7t7c coloured by chain, side view.
PDB entry 7t7c coloured by chain, top view.
Source organisms:
Primary publication:
Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release.
Grushin K, Kalyana Sundaram RV, Sindelar CV, Rothman JE
Proc Natl Acad Sci U S A 119 (2022)
PMID: 35135883
Related structures: EMD-25737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243327 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein unc-13 homolog A; Unc-13 homolog A Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 1154 amino acids
Theoretical weight: 130.9 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q4KUS2 (Residues: 525-656, 1448-1712; Coverage: 23%)
  • Canonical: A0A822AJ50 (Residues: 657-1403; Coverage: 43%)
Gene names: RIMITATOR_LOCUS6943369, Unc13a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10Å
Relevant EMDB volumes: EMD-25737
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy.
Cui et al. (2022)
8 more

1 mention without citation

Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles.
Li et al. (2023)