Structure analysis

Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin

X-ray diffraction
2.46Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 19688.31 Å2
Buried surface area: 1248.27 Å2
Dissociation area: 624.14 Å2
Dissociation energy (ΔGdiss): 17.51 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149068
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 20085.12 Å2
Buried surface area: 1257.09 Å2
Dissociation area: 628.54 Å2
Dissociation energy (ΔGdiss): 19.05 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149068
Assembly 3
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Multimeric state: monomeric
Accessible surface area: 19381.93 Å2
Buried surface area: 1246.19 Å2
Dissociation area: 623.09 Å2
Dissociation energy (ΔGdiss): 15.63 kcal/mol
Dissociation entropy (TΔSdiss): 5.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149068
Assembly 4
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Multimeric state: monomeric
Accessible surface area: 19054.0 Å2
Buried surface area: 1249.37 Å2
Dissociation area: 624.68 Å2
Dissociation energy (ΔGdiss): 19.15 kcal/mol
Dissociation entropy (TΔSdiss): 5.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149068

Macromolecules

Chains: A, B, C, D
Length: 480 amino acids
Theoretical weight: 54.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20815 (Residues: 22-22, 24-497; Coverage: 95%)
Gene name: CYP3A5
Pfam: Cytochrome P450
InterPro:

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