7slv

X-ray diffraction
2.13Å resolution

Vanin-1 complexed with Compound 3

Released:
Source organism: Homo sapiens
Entry author: Vajdos FF

Function and Biology Details

Reaction catalysed:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Pantetheinase Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 53.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O95497 (Residues: 22-483; Coverage: 94%)
Gene name: VNN1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 64.656Å b: 111.511Å c: 147.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.223
Expression system: Cricetulus griseus