› 7si4

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF EED WITH MRTX-2219

Released:
DOI: 10.2210/pdb7si4/pdb
PDB entry 7si4 coloured by chain, front view.
PDB entry 7si4 coloured by chain, side view.
PDB entry 7si4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gunn RJ, Burns AC, Lawson JD, Marx MA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 46.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 40-441; Coverage: 91%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

2 bound ligands:
Ligand 9JL 1 x 9JL
Ligand FMT 2 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 57.658Å b: 85.279Å c: 91.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.213
Expression system: Escherichia coli

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