› 7s7g

X-ray diffraction
1.34Å resolution

Crystal Structure Analysis of Human VLCAD

Released:
DOI: 10.2210/pdb7s7g/pdb
PDB entry 7s7g coloured by chain, front view.
PDB entry 7s7g coloured by chain, side view.
PDB entry 7s7g coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Seo H-S, Dhe-Paganon S

Function and Biology Details

Reaction catalysed: 
A very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 617 amino acids
Theoretical weight: 66.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49748 (Residues: 69-655; Coverage: 90%)
Gene names: ACADVL, VLCAD
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 75.26Å b: 108.27Å c: 149.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.146 0.168
Expression system: Escherichia coli BL21(DE3)

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