7s61

Electron Microscopy
4Å resolution

Human KATP channel in open conformation, focused on Kir and one SUR, position 5

Released:
Source organism: Homo sapiens
Primary publication:
Molecular structure of an open human KATP channel.
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34815345
Related structures: EMD-24846

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-170790 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 390 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14654 (Residues: 1-390; Coverage: 100%)
Gene name: KCNJ11
Sequence domains:
ATP-binding cassette sub-family C member 8 Chain: E
Molecule details ›
Chain: E
Length: 1582 amino acids
Theoretical weight: 177.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q09428 (Residues: 2-1581; Coverage: 100%)
Gene names: ABCC8, HRINS, SUR, SUR1
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-24846
Expression system: Homo sapiens