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Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-(((pyridin-2-ylmethyl)amino)methyl)phenoxy)methyl)quinolin-2-amine

Source organism: Rattus norvegicus
Biochemical function: nitric-oxide synthase activity
Biological process: nitric oxide biosynthetic process
Cellular component: not assigned

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EC 1.14.13.39: Nitric-oxide synthase (NADPH)

Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Systematic name:
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
  • Endothelium-derived relaxation factor-forming enzyme
  • Endothelium-derived relaxing factor synthase
  • NADPH-diaphorase
  • NO synthase
  • NOS (gene name)
  • Nitric oxide synthetase
  • Nitric-oxide synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02898
Domain description: Nitric oxide synthase, oxygenase domain
Occurring in:
  1. Nitric oxide synthase 1
The deposited structure of PDB entry 7s3x contains 2 copies of Pfam domain PF02898 (Nitric oxide synthase, oxygenase domain) in Nitric oxide synthase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR004030
Domain description: Nitric oxide synthase, N-terminal
Occurring in:
  1. Nitric oxide synthase 1
IPR044944
Domain description: Nitric oxide synthase, domain 3 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR044940
Domain description: Nitric oxide synthase, domain 2 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR044943
Domain description: Nitric oxide synthase, domain 1 superfamily
Occurring in:
  1. Nitric oxide synthase 1
IPR036119
Domain description: Nitric oxide synthase, N-terminal domain superfamily
Occurring in:
  1. Nitric oxide synthase 1

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