› 7ry1

X-ray diffraction
3.52Å resolution

human Hsp90_MC domain structure

Released:
DOI: 10.2210/pdb7ry1/pdb
PDB entry 7ry1 coloured by chain, front view.
PDB entry 7ry1 coloured by chain, side view.
PDB entry 7ry1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
Peng S, Woodruff J, Pathak PK, Matts RL, Deng J
Acta Crystallogr D Struct Biol 78 571-585 (2022)
PMID: 35503206

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 425 amino acids
Theoretical weight: 49.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 293-714; Coverage: 58%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Hsp90 protein

Ligands and Environments

1 bound ligand:
Ligand MDC 3 x MDC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 159.85Å b: 311.964Å c: 88.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.216 0.272
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structural and functional complexity of HSP90 in cellular homeostasis and disease.
Chiosis et al. (2023)
1 more

3 mentions without citation

Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
Peng et al. (2022)
2 more