› 7rtf

Electron Microscopy
2.9Å resolution

SthK R120A Closed State

Released:
DOI: 10.2210/pdb7rtf/pdb
PDB entry 7rtf coloured by chain, front view.
PDB entry 7rtf coloured by chain, side view.
PDB entry 7rtf coloured by chain, top view.
Source organism: Spirochaeta thermophila
Primary publication:
Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Gao X, Schmidpeter PAM, Berka V, Durham RJ, Fan C, Jayaraman V, Nimigean CM
Nat Commun 13 6919 (2022)
PMID: 36376326
Related structures: EMD-24681

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-binding domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 456 amino acids
Theoretical weight: 51.03 KDa
Source organism: Spirochaeta thermophila
Expression system: Escherichia coli
UniProt:
  • Canonical: G0GA88 (Residues: 1-430; Coverage: 100%)
Gene name: Spith_0644
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CMP 4 x CMP
Ligand PGW 48 x PGW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24681
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Hu et al. (2023)

1 mention without citation

Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels.
Hu et al. (2023)