› 7rkp

X-ray diffraction
2.36Å resolution

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733

Released:
DOI: 10.2210/pdb7rkp/pdb
PDB 7rkp coloured by chain and viewed from the front.
PDB 7rkp coloured by chain and viewed from the side.
PDB 7rkp coloured by chain and viewed from the top.
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Entry authors: Cuypers MG, Slavish JP, Rankovic Z, White SW

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 23.14 KDa
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C3W5S0 (Residues: 1-50, 73-196; Coverage: 24%)
Gene name: PA

Ligands and Environments

4 bound ligands:
Ligand QQ4 1 x QQ4
Ligand 5Y1 1 x 5Y1
Ligand MN 2 x MN
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: I422
Unit cell:
a: 89.69Å b: 89.69Å c: 133.156Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.255
Expression system: Escherichia coli BL21(DE3)

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