7rco

X-ray diffraction
2.9Å resolution

Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab

Released:
Source organism: Homo sapiens
Entry authors: Yin J, Lupardus PJ, Sudhamsu J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transforming growth factor beta-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P61812 (Residues: 303-414; Coverage: 28%)
Gene name: TGFB2
Sequence domains: Transforming growth factor beta like domain
4A11.V2 Fab Light Chain Chains: C, E
Molecule details ›
Chains: C, E
Length: 219 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
4A11.V2 Fab Heavy Chain Chains: D, F
Molecule details ›
Chains: D, F
Length: 233 amino acids
Theoretical weight: 24.39 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Unit cell:
a: 60.154Å b: 103.479Å c: 196.253Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.208 0.286
Expression system: Cricetulus griseus