X-ray diffraction
2.76Å resolution

Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 21


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Toll-like receptor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 811 amino acids
Theoretical weight: 92.84 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
  • Canonical: Q9NR97 (Residues: 27-827; Coverage: 79%)
Gene names: TLR8, UNQ249/PRO286
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 160.889Å b: 83.876Å c: 153.524Å
α: 90° β: 119.72° γ: 90°
R R work R free
0.235 0.234 0.262
Expression system: Drosophila melanogaster