› 7qpz

X-ray diffraction
1.45Å resolution

X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (4)

Released:
DOI: 10.2210/pdb7qpz/pdb
PDB entry 7qpz coloured by chain, front view.
PDB entry 7qpz coloured by chain, side view.
PDB entry 7qpz coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Reactivity of a fluorine-containing dirhodium tetracarboxylate compound with proteins.
Loreto D, Esposito A, Demitri N, Guaragna A, Merlino A
Dalton Trans 51 3695-3705 (2022)
PMID: 35166290

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease

Ligands and Environments

2 bound ligands:
Ligand F5T 1 x F5T
Ligand F5I 2 x F5I
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: C2
Unit cell:
a: 100.73Å b: 32.87Å c: 72.89Å
α: 90° β: 90.154° γ: 90°
R-values:
R R work R free
0.164 0.162 0.202

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Citations

3 citation in other articles

A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action.
La Manna et al. (2024)
2 more