X-ray diffraction
3Å resolution

Crystal structure of a mutant (P393GX) Thyroid Receptor Alpha ligand binding domain designed to model dominant negative human mutations.


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10827 (Residues: 156-370; Coverage: 44%)
  • Best match: P10827-2 (Residues: 156-391)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6422
Unit cell:
a: 143.328Å b: 143.328Å c: 88.502Å
α: 90° β: 90° γ: 120°
R R work R free
0.186 0.183 0.228
Expression system: Escherichia coli