X-ray diffraction
1.85Å resolution

mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT218


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hydroxymycolate synthase MmaA4 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.52 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q79FX8 (Residues: 4-301; Coverage: 99%)
Gene names: Rv0642c, hma, mma4, mmaA4
Sequence domains: Mycolic acid cyclopropane synthetase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 57.289Å b: 57.289Å c: 205.992Å
α: 90° β: 90° γ: 120°
R R work R free
0.169 0.167 0.206
Expression system: Escherichia coli BL21(DE3)