X-ray diffraction
1.8Å resolution

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Iberdomide (CC-220)

Entry authors: Heim C, Hartmann MD

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
CULT domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 124 amino acids
Theoretical weight: 13.63 KDa
Source organism: Magnetospirillum gryphiswaldense
Expression system: Escherichia coli BL21(DE3)
  • Canonical: A4TVL0 (Residues: 1-124; Coverage: 100%)
Gene name: MGR_0879

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 56.001Å b: 58.85Å c: 88.583Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.193 0.246
Expression system: Escherichia coli BL21(DE3)