7pcj

X-ray diffraction
1.91Å resolution

X-ray structure of CypA-C52AK125C/CsA/aromatic foldamer complex

Released:
Entry authors: Vallade M, Langlois d'Estaintot B, Fischer L, Buratto J, Savko M, Huc I

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chains: A, D
Molecule details ›
Chains: A, D
Length: 165 amino acids
Theoretical weight: 18.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Cyclosporin A Chains: B, E
Molecule details ›
Chains: B, E
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P21
Unit cell:
a: 42.474Å b: 70.891Å c: 64.09Å
α: 90° β: 102.7° γ: 90°
R-values:
R R work R free
0.179 0.177 0.219
Expression system: Escherichia coli BL21(DE3)