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BurG (holo) in complex with hydroxypyruvate-enol (8): Biosynthesis of cyclopropanol rings in bacterial toxins

Source organism: Burkholderia thailandensis E264
Biochemical function: metal ion binding
Biological process: valine biosynthetic process
Cellular component: cytosol

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EC 1.1.1.86: Ketol-acid reductoisomerase (NADP(+))

Reaction catalysed:
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH
Systematic name:
(2R)-2,3-dihydroxy-3-methylbutanoate:NADP(+) oxidoreductase (isomerizing)
Alternative Name(s):
  • (R)-2,3-dihydroxy-3-methylbutanoate:NADP(+) oxidoreductase (isomerizing)
  • 2-hydroxy-3-keto acid reductoisomerase
  • Acetohydroxy acid isomeroreductase
  • Acetohydroxy acid reductoisomerase
  • Acetolactate reductoisomerase
  • Alpha-keto-beta-hydroxylacyl reductoisomerase
  • Dihydroxyisovalerate (isomerizing) dehydrogenase
  • Dihydroxyisovalerate dehydrogenase (isomerizing)
  • Isomeroreductase
  • Ketol acid reductoisomerase
  • Ketol-acid reductoisomerase
  • Reductoisomerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01450
Domain description: Acetohydroxy acid isomeroreductase, catalytic domain
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
The deposited structure of PDB entry 7pci contains 1 copy of Pfam domain PF01450 (Acetohydroxy acid isomeroreductase, catalytic domain) in Ketol-acid reductoisomerase (NADP(+)). Showing 1 copy in chain A.

PF07991
Domain description: Acetohydroxy acid isomeroreductase, NADPH-binding domain
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
The deposited structure of PDB entry 7pci contains 1 copy of Pfam domain PF07991 (Acetohydroxy acid isomeroreductase, NADPH-binding domain) in Ketol-acid reductoisomerase (NADP(+)). Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000506
Domain description: Ketol-acid reductoisomerase, C-terminal
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
IPR013116
Domain description: Ketol-acid reductoisomerase, N-terminal
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
IPR008927
Domain description: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
IPR013023
Domain description: Ketol-acid reductoisomerase
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
IPR015878
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Ketol-acid reductoisomerase (NADP(+))

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