› 7pac

X-ray diffraction
2.05Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129171 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Chain: B
Molecule details ›
Chain: B
Length: 166 amino acids
Theoretical weight: 19.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43924 (Residues: 2-150; Coverage: 99%)
Gene names: PDE6D, PDED
Sequence domains: GMP-PDE, delta subunit

Ligands and Environments

2 bound ligands:
Ligand NI 1 x NI
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 44.25Å b: 39.18Å c: 44.68Å
α: 90° β: 105.89° γ: 90°
R-values:
R R work R free
0.188 0.186 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway.
Harwood et al. (2023)