› 7p8s

X-ray diffraction
1.9Å resolution

Crystal Structure of leukotoxin LukE from Staphylococcus aureus at 1.9 Angstrom resolution

Released:
DOI: 10.2210/pdb7p8s/pdb
PDB entry 7p8s coloured by chain, front view.
PDB entry 7p8s coloured by chain, side view.
PDB entry 7p8s coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.
Lambey P, Otun O, Cong X, Hoh F, Brunel L, Verdié P, Grison CM, Peysson F, Jeannot S, Durroux T, Bechara C, Granier S, Leyrat C
Elife 11 (2022)
PMID: 35311641

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucotoxin LukEv Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 34.69 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FXB0 (Residues: 6-306; Coverage: 100%)
Gene names: SAOUHSC_01955, lukEv
Sequence domains: Leukocidin/Hemolysin toxin family

Ligands and Environments

3 bound ligands:
Ligand P6G 1 x P6G
Ligand MHA 1 x MHA
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: I4
Unit cell:
a: 135.79Å b: 135.79Å c: 63.533Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.203
Expression system: Escherichia coli

Quick links

Citations

2 review citations

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications.
Feng et al. (2023)
1 more

1 mention without citation

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.
Lambey et al. (2022)