› 7p6y

X-ray diffraction
1.88Å resolution

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 5ef

Released:
DOI: 10.2210/pdb7p6y/pdb
PDB entry 7p6y coloured by chain, front view.
PDB entry 7p6y coloured by chain, side view.
PDB entry 7p6y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
Fallon DJ, Lehmann S, Chung CW, Phillipou A, Eberl C, Fantom KGM, Zappacosta F, Patel VK, Bantscheff M, Schofield CJ, Tomkinson NCO, Bush JT
Chemistry 27 17880-17888 (2021)
PMID: 34328642

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand 5Z1 2 x 5Z1
No modified residues

Experiments and Validation Details

Entry percentile scores
R-values:
R R work R free
0.179 0.177 0.222
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

A direct-to-biology high-throughput chemistry approach to reactive fragment screening.
Thomas et al. (2021)
3 more