› 7p6t

X-ray diffraction
1.4Å resolution

Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)

Released:
DOI: 10.2210/pdb7p6t/pdb
PDB entry 7p6t coloured by chain, front view.
PDB entry 7p6t coloured by chain, side view.
PDB entry 7p6t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L
Nat Struct Mol Biol 29 190-193 (2022)
PMID: 35273390

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic secretory granule membrane major glycoprotein GP2 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55259 (Residues: 29-184; Coverage: 30%)
Gene name: GP2

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand 9D2 5 x 9D2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: C2
Unit cell:
a: 90.15Å b: 33.66Å c: 59.63Å
α: 90° β: 111.839° γ: 90°
R-values:
R R work R free
0.197 0.195 0.224
Expression system: Homo sapiens

Quick links

Citations

2 review citations

AlphaFold2 and its applications in the fields of biology and medicine.
Yang et al. (2023)
1 more