› 7ozx

X-ray diffraction
2.3Å resolution

Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone

Released:
DOI: 10.2210/pdb7ozx/pdb
PDB entry 7ozx coloured by chain, front view.
PDB entry 7ozx coloured by chain, side view.
PDB entry 7ozx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mackinnon SR, Bezerra GA, Zhang M, Foster W, Krojer T, Brandao-Neto J, Arrowsmith C, Edwards A, Bountra C, Brennan P, Lai K, Yue WW

Function and Biology Details

Reaction catalysed: 
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 399 amino acids
Theoretical weight: 43.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51570 (Residues: 2-392; Coverage: 100%)
Gene names: GALK, GALK1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GAL 3 x GAL
Ligand HFK 3 x HFK
Ligand WLJ 2 x WLJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 73.456Å b: 114.499Å c: 120.822Å
α: 90° β: 100.57° γ: 90°
R-values:
R R work R free
0.211 0.208 0.258
Expression system: Escherichia coli BL21(DE3)

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