› 7omq

X-ray diffraction
1.45Å resolution

SaFtsZ complexed with GDPPCP and Mn2+

Released:
DOI: 10.2210/pdb7omq/pdb
PDB entry 7omq coloured by chain, front view.
PDB entry 7omq coloured by chain, side view.
PDB entry 7omq coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics.
Ruiz FM, Huecas S, Santos-Aledo A, Prim EA, Andreu JM, Fernández-Tornero C
PLoS Biol 20 e3001497 (2022)
PMID: 35312677

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsZ Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 31.94 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2FZ89 (Residues: 12-316; Coverage: 78%)
Gene names: SAOUHSC_01150, ftsZ
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GCP 1 x GCP
Ligand MN 1 x MN
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: C2
Unit cell:
a: 70.89Å b: 52.055Å c: 87.937Å
α: 90° β: 110.336° γ: 90°
R-values:
R R work R free
0.162 0.161 0.187
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites.
Andreu et al. (2022)
1 more