› 7ol3

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Atlastin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 458 amino acids
Theoretical weight: 52.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXF7 (Residues: 1-416, 417-449; Coverage: 81%)
Gene names: ATL1, GBP3, SPG3A
Sequence domains: Guanylate-binding protein, N-terminal domain

Ligands and Environments

3 bound ligands:
Ligand GDP 2 x GDP
Ligand ALF 2 x ALF
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P212121
Unit cell:
a: 49.09Å b: 115.003Å c: 184.008Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

De novo variants cause complex symptoms in HSP-ATL1 (SPG3A) and uncover genotype-phenotype correlations.
Alecu et al. (2023)
2 more

1 mention without citation

A novel insertion mutation in atlastin 1 is associated with spastic quadriplegia, increased membrane tethering, and aberrant conformational switching.
Kelly et al. (2022)