› 7ojq

X-ray diffraction
1.87Å resolution

Function and Biology Details

Reaction catalysed: 
A (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = an [acyl-carrier-protein] + a UDP-3-O-(3-hydroxyacylyl)-N-acetyl-alpha-D-glucosamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 261 amino acids
Theoretical weight: 28.33 KDa
Source organism: Pseudomonas aeruginosa PA7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9X6P4 (Residues: 1-258; Coverage: 100%)
Gene names: PA3644, lpxA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand VJE 3 x VJE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I41
Unit cell:
a: 166.68Å b: 166.68Å c: 98.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics.
Murugaiyan et al. (2022)
4 more