7o2i

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N6-adenosine-methyltransferase catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 26.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86U44 (Residues: 353-580; Coverage: 39%)
Gene names: METTL3, MTA70
Sequence domains: MT-A70
N6-adenosine-methyltransferase non-catalytic subunit Chain: B
Molecule details ›
Chain: B
Length: 291 amino acids
Theoretical weight: 33.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HCE5 (Residues: 107-395; Coverage: 63%)
Gene names: KIAA1627, METTL14
Sequence domains: MT-A70

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3221
Unit cell:
a: 64.094Å b: 64.094Å c: 225.302Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.263
Expression system: Spodoptera frugiperda