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Crystal structure of the human METTL3-METTL14 complex bound to Compound 21 (ADO_AD_089)

Source organism: Homo sapiens
Biochemical function: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
Biological process: RNA methylation
Cellular component: nucleus

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EC 2.1.1.348: mRNA m(6)A methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
Systematic name:
S-adenosyl-L-methionine:adenine in mRNA methyltransferase
Alternative Name(s):
  • METTL14 (gene name)
  • METTL3 (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF05063
Domain description: MT-A70
Occurring in:
  1. N6-adenosine-methyltransferase catalytic subunit
  2. N6-adenosine-methyltransferase non-catalytic subunit
The deposited structure of PDB entry 7o2e contains 1 copy of Pfam domain PF05063 (MT-A70 ) in N6-adenosine-methyltransferase catalytic subunit. Showing 1 copy in chain A.
The deposited structure of PDB entry 7o2e contains 1 copy of Pfam domain PF05063 (MT-A70 ) in N6-adenosine-methyltransferase non-catalytic subunit. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR007757
Domain description: MT-A70-like
Occurring in:
  1. N6-adenosine-methyltransferase catalytic subunit
  2. N6-adenosine-methyltransferase non-catalytic subunit
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. N6-adenosine-methyltransferase catalytic subunit
  2. N6-adenosine-methyltransferase non-catalytic subunit
IPR045123
Domain description: N6-adenosine-methyltransferase non-catalytic subunit METTL14-like
Occurring in:
  1. N6-adenosine-methyltransferase non-catalytic subunit
IPR025848
Domain description: N6-adenosine-methyltransferase MT-A70-like
Occurring in:
  1. N6-adenosine-methyltransferase catalytic subunit
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. N6-adenosine-methyltransferase catalytic subunit

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