7nz7

X-ray diffraction
2.96Å resolution

Function and Biology Details

Reaction catalysed:
Adenine(34) in tRNA + H(2)O = hypoxanthine(34) in tRNA + NH(3)
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
tRNA-specific adenosine deaminase 2 Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P6J0 (Residues: 1-191; Coverage: 100%)
Gene names: Adat2, Deadc1
Sequence domains: Cytidine and deoxycytidylate deaminase zinc-binding region
Probable inactive tRNA-specific adenosine deaminase-like protein 3 Chain: B
Molecule details ›
Chain: B
Length: 317 amino acids
Theoretical weight: 34.22 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PAT0 (Residues: 1-349; Coverage: 91%)
Gene name: Adat3
Sequence domains: Cytidine and deoxycytidylate deaminase zinc-binding region

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 105.471Å b: 105.471Å c: 187.076Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.233
Expression system: Escherichia coli