X-ray diffraction
1.9Å resolution

Crystal structure of the TIR domain of human TLR1 (crystallised with Zn2+ ions)


Function and Biology Details

Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Toll-like receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q15399 (Residues: 625-785; Coverage: 21%)
Gene names: KIAA0012, TLR1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6222
Unit cell:
a: 101.516Å b: 101.516Å c: 68.86Å
α: 90° β: 90° γ: 120°
R R work R free
0.217 0.215 0.245
Expression system: Escherichia coli BL21(DE3)