X-ray diffraction
1.54Å resolution

Crystal structure of Mycobacterium tuberculosis ArgD with prosthetic group pyridoxal 5'-phosphate


Function and Biology Details

Reaction catalysed:
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Acetylornithine aminotransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 402 amino acids
Theoretical weight: 41.33 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WPZ7 (Residues: 1-400; Coverage: 100%)
Gene names: MTCY06H11.20, Rv1655, argD
Sequence domains: Aminotransferase class-III

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 65.055Å b: 184.265Å c: 71.545Å
α: 90° β: 106.1° γ: 90°
R R work R free
0.178 0.177 0.199
Expression system: Escherichia coli BL21(DE3)