› 7nmf

X-ray diffraction
2.98Å resolution

Human MHC Class I, A24 Allele presenting QLPRLFPLL, Complex with 4C6 TCR, monoclinic form

Released:
DOI: 10.2210/pdb7nmf/pdb
PDB 7nmf coloured by chain and viewed from the front.
PDB 7nmf coloured by chain and viewed from the side.
PDB 7nmf coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Rizkallah PJ, Sewell AK, Cole DK, Wall A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A411J078 (Residues: 25-300; Coverage: 87%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
GLN-LEU-PRO-ARG-LEU-PHE-PRO-LEU-LEU Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
Human T-cell Receptor 4C6, alpha Chain Chain: D
Molecule details ›
Chain: D
Length: 194 amino acids
Theoretical weight: 21.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Human T-cell Receptor 4C6, beta Chain Chain: E
Molecule details ›
Chain: E
Length: 240 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand MES 1 x MES
Ligand EDO 1 x EDO
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 63.38Å b: 72.25Å c: 114.84Å
α: 90° β: 102.98° γ: 90°
R-values:
R R work R free
0.186 0.182 0.259
Expression systems:
  • Escherichia coli
  • Not provided

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