› 7n8r

X-ray diffraction
1.2Å resolution

FGTGFG segment from the Nucleoporin p54, residues 63-68

Released:
DOI: 10.2210/pdb7n8r/pdb
PDB entry 7n8r coloured by chain, front view.
PDB entry 7n8r coloured by chain, side view.
PDB entry 7n8r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Extended β-Strands Contribute to Reversible Amyloid Formation.
Murray KA, Evans D, Hughes MP, Sawaya MR, Hu CJ, Houk KN, Eisenberg D
ACS Nano 16 2154-2163 (2022)
PMID: 35132852

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoporin p54 Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 585 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7Z3B4 (Residues: 63-68; Coverage: 1%)
Gene name: NUP54

Ligands and Environments

1 bound ligand:
Ligand TFA 1 x TFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 15.71Å b: 9.4Å c: 23.26Å
α: 90° β: 108.52° γ: 90°
R-values:
R R work R free
0.146 0.143 0.174
Expression system: Not provided

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Citations

5 citation in other articles

Bioinformatic identification of previously unrecognized amyloidogenic proteins.
Rosenberg et al. (2022)
4 more