› 7n1o

X-ray diffraction
2.77Å resolution

The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone

Released:
DOI: 10.2210/pdb7n1o/pdb
PDB entry 7n1o coloured by chain, front view.
PDB entry 7n1o coloured by chain, side view.
PDB entry 7n1o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystals of TELSAM-target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts.
Nawarathnage S, Soleimani S, Mathis MH, Bezzant BD, Ramírez DT, Gajjar P, Bunn DR, Stewart C, Smith T, Pedroza Romo MJ, Brown S, Doukov T, Moody JD
Open Biol 12 210271 (2022)
PMID: 35232248

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154333 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anthrax toxin receptor 2; Transcription factor ETV6 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41212 (Residues: 46-123; Coverage: 17%)
  • Canonical: P58335 (Residues: 40-217; Coverage: 39%)
Gene names: ANTXR2, CMG2, ETV6, TEL, TEL1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P65
Unit cell:
a: 103.396Å b: 103.396Å c: 56.55Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.203 0.228
Expression system: Escherichia coli

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Citations

1 citations in other articles

Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Kottur et al. (2023)

5 mentions without citation

High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
Kottur et al. (2022)
4 more