Function and Biology Details
Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase S3, togavirin
- Low-density lipoprotein (LDL) receptor class A repeat
- Flaviviral glycoprotein E, dimerisation domain
- LDL receptor-like superfamily
- Peptidase S1, PA clan, chymotrypsin-like fold
- Low-density lipoprotein (LDL) receptor class A, conserved site
- Peptidase S1, PA clan
- Alphavirus E2 glycoprotein, domain C
7 more domains
Structure analysis Details
Assembly composition:
hetero 960-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101064 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Low-density lipoprotein receptor class A domain-containing protein 3
Molecule details ›
Chains: M, N, O, P
Length: 39 amino acids
Theoretical weight: 4.31 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
Sequence domains: Low-density lipoprotein receptor domain class A
Length: 39 amino acids
Theoretical weight: 4.31 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
- Canonical:
A2AR95 (Residues: 28-66; Coverage: 12%)
Sequence domains: Low-density lipoprotein receptor domain class A
p130
Molecule details ›
Chains: A, B, C, D
Length: 442 amino acids
Theoretical weight: 47.95 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
Length: 442 amino acids
Theoretical weight: 47.95 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
- Canonical: A0A0C4MX98 (Residues: 814-1255; Coverage: 35%)
p130
Molecule details ›
Chains: E, F, G, H
Length: 423 amino acids
Theoretical weight: 47.11 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
Length: 423 amino acids
Theoretical weight: 47.11 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
- Canonical: A0A0C4MX98 (Residues: 335-757; Coverage: 34%)
p130
Molecule details ›
Chains: I, J, K, L
Length: 162 amino acids
Theoretical weight: 18.2 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
Length: 162 amino acids
Theoretical weight: 18.2 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
UniProt:
- Canonical: A0A0C4MX98 (Residues: 114-275; Coverage: 13%)
