7n0a

X-ray diffraction
3.1Å resolution

Structure of Human Leukaemia Inhibitory Factor with Fab MSC1

Released:
Source organism: Homo sapiens
Entry authors: Raman S, Bosch A, Fransson J, Julien JP

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Leukemia inhibitory factor Chain: C
Molecule details ›
Chain: C
Length: 181 amino acids
Theoretical weight: 19.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15018 (Residues: 23-202; Coverage: 100%)
Gene names: HILDA, LIF
Sequence domains: LIF / OSM family
MSC-1 Fab Light chain Chain: A
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 24.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
MSC-1 Fab Heavy chain Chain: B
Molecule details ›
Chain: B
Length: 224 amino acids
Theoretical weight: 24.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21212
Unit cell:
a: 60.572Å b: 109.38Å c: 115.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.284
Expression system: Homo sapiens