› 7msd

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 42.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 77-441; Coverage: 83%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

2 bound ligands:
Ligand ZMY 1 x ZMY
Ligand FMT 1 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 57.8Å b: 85.57Å c: 91.916Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.212
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The roles of EZH2 in cancer and its inhibitors.
Liu et al. (2023)
2 more

1 mention without citation

Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
Rej et al. (2021)