› 7mrm

X-ray diffraction
2.75Å resolution

Chicken CNTN3 APP complex

Released:
DOI: 10.2210/pdb7mrm/pdb
PDB entry 7mrm coloured by chain, front view.
PDB entry 7mrm coloured by chain, side view.
PDB entry 7mrm coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface.
Karuppan SJ, Vogt A, Fischer Z, Ladutska A, Swiastyn J, McGraw HF, Bouyain S
J Biol Chem 298 101541 (2022)
PMID: 34958801

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238423 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta A4 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 397 amino acids
Theoretical weight: 43.42 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9DGJ7 (Residues: 4-4, 19-199; Coverage: 23%)
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 69.669Å b: 94.5Å c: 174.149Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.231
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology.
Pfundstein et al. (2022)
1 more

1 mention without citation

Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface.
Karuppan et al. (2022)