7mrc

X-ray diffraction
1.55Å resolution

Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-II-052

Released:
Source organism: Homo sapiens
Entry authors: Chan A, Schonbrunn E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain testis-specific protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q58F21 (Residues: 29-137; Coverage: 12%)
  • Best match: Q58F21-5 (Residues: 1-64)
Gene name: BRDT
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 62.36Å b: 34.89Å c: 110.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.195
Expression system: Escherichia coli BL21(DE3)