7mo8

Electron Microscopy
4.5Å resolution

Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of the activation of c-MET receptor.
Nat Commun 12 4074 (2021)
PMID: 34210960
Related structures: EMD-23920

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hepatocyte growth factor Chain: A
Molecule details ›
Chain: A
Length: 728 amino acids
Theoretical weight: 83.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14210 (Residues: 1-728; Coverage: 100%)
Gene names: HGF, HPTA
Sequence domains:
Hepatocyte growth factor receptor Chain: B
Molecule details ›
Chain: B
Length: 1390 amino acids
Theoretical weight: 155.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08581 (Residues: 1-1390; Coverage: 100%)
Gene name: MET
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-23920
Expression system: Homo sapiens