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› 7mkk

X-ray diffraction
2.5Å resolution

Crystal structure of Drosophila Panoramix in complex with Sov NTD

Released:
DOI: 10.2210/pdb7mkk/pdb
PDB entry 7mkk coloured by chain, front view.
PDB entry 7mkk coloured by chain, side view.
PDB entry 7mkk coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J
Nat Struct Mol Biol 29 130-142 (2022)
PMID: 35173350

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194336 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C2H2-type domain-containing protein Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 78 amino acids
Theoretical weight: 9.26 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9W3W6 (Residues: 14-90; Coverage: 2%)
Gene names: CG14438, Dmel\CG14438, Dmel_CG14438, EM25, Sov, fs(1)A1304, fs(1)M105, l(1)6Dc, l(1)EA42, l(1)EM25, sov
Protein panoramix Chains: C, D, F, H
Molecule details ›
Chains: C, D, F, H
Length: 28 amino acids
Theoretical weight: 3.09 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9W2H9 (Residues: 83-109; Coverage: 5%)
Gene names: CG9754, Panx

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P6422
Unit cell:
a: 127.389Å b: 127.389Å c: 96.012Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.227 0.26
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

All Quiet on the TE Front? The Role of Chromatin in Transposable Element Silencing.
Di Stefano L. (2022)
1 more