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Multidrug Efflux pump AdeJ with Eravacycline bound

Electron Microscopy
2.86Å resolution
PDB entry 7m4p coloured by chain, front view.
PDB entry 7m4p coloured by chain, side view.
PDB entry 7m4p coloured by chain, top view.
Source organism: Acinetobacter baumannii
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Efflux pump membrane transporter
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Multimeric state: homo trimer
Accessible surface area: 123159.63 Å2
Buried surface area: 24657.14 Å2
Dissociation area: 6,097.47 Å2
Dissociation energy (ΔGdiss): 53 kcal/mol
Dissociation entropy (TΔSdiss): 18.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-173395

Macromolecules

Efflux pump membrane transporter
Chains: A, B, C
Length: 1058 amino acids
Theoretical weight: 114.64 KDa
Source organism: Acinetobacter baumannii
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q2FD94 (Residues: 1-1058; Coverage: 100%)
Gene names: 16_18, A7M90_18260, ABR2091_2941, ABUW_0843, B9W25_10035, B9X95_17010, CAS83_01890, CBE85_16500, CV954_003755, DOL94_01575, F2P40_15340, F4T85_03325, FJU42_11415, G3N53_18475, GNY86_00640, GSE42_16275, IAG11_12040, ITE13_15860, JHZ39_002181, MKP18_003079, SAMEA104305318_02843, SAMEA4394745_03226, adeJ, mexB_2
Pfam: AcrB/AcrD/AcrF family
InterPro:
Efflux pump membrane transporter in PDB entry 7m4p, assembly 1, front view.
Efflux pump membrane transporter in PDB entry 7m4p, assembly 1, side view.
Efflux pump membrane transporter in PDB entry 7m4p, assembly 1, top view.
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