7lwh

X-ray diffraction
1.61Å resolution

Human neurofibromin 2/merlin residues 1-339 in complex with LATS1

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Merlin Chain: A
Molecule details ›
Chain: A
Length: 339 amino acids
Theoretical weight: 40.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35240 (Residues: 1-339; Coverage: 57%)
  • Best match: P35240-7 (Residues: 1-258)
Gene names: NF2, SCH
Sequence domains:
Serine/threonine-protein kinase LATS1 Chain: B
Molecule details ›
Chain: B
Length: 23 amino acids
Theoretical weight: 2.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95835 (Residues: 69-91; Coverage: 2%)
Gene names: LATS1, WARTS

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 52.241Å b: 84.241Å c: 95.859Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.232
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided