› 7lvi

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AP2-associated protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 318 amino acids
Theoretical weight: 35.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3UHJ0 (Residues: 26-330; Coverage: 32%)
Gene names: Aak1, Kiaa1048
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand YFY 1 x YFY
Ligand SO4 3 x SO4
Ligand YFV 1 x YFV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3121
Unit cell:
a: 91.356Å b: 91.356Å c: 172.868Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.218 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Dzierba et al. (2023)

2 mentions without citation

Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents.
Yuan et al. (2023)
1 more