7lro

X-ray diffraction
1.45Å resolution

Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105

Released:
Source organism: Homo sapiens
Entry authors: Chan A, Schonbrunn E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome-remodeling factor subunit BPTF Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12830 (Residues: 2917-3037; Coverage: 4%)
Gene names: BPTF, FAC1, FALZ
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 58.41Å b: 27.07Å c: 76.92Å
α: 90° β: 93.87° γ: 90°
R-values:
R R work R free
0.16 0.159 0.191
Expression system: Escherichia coli BL21(DE3)