› 7lro

X-ray diffraction
1.45Å resolution

Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105

Released:
DOI: 10.2210/pdb7lro/pdb
PDB 7lro coloured by chain and viewed from the front.
PDB 7lro coloured by chain and viewed from the side.
PDB 7lro coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Chan A, Schonbrunn E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome-remodeling factor subunit BPTF Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12830 (Residues: 2917-3037; Coverage: 4%)
Gene names: BPTF, FAC1, FALZ
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand DMS 1 x DMS
Ligand YBV 2 x YBV
Ligand EDO 12 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 58.41Å b: 27.07Å c: 76.92Å
α: 90° β: 93.87° γ: 90°
R-values:
R R work R free
0.16 0.159 0.191
Expression system: Escherichia coli BL21(DE3)

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