PDB 7lmx structure summary ‹ Protein Data Bank in Europe (PDBe)

X-ray diffraction

1.8Å resolution

A HIGHLY SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6 WITH A DISULFIDE

Released: 10 Aug 2022

DOI: 10.2210/pdb7lmx/pdb

Source organism: synthetic construct

Primary publication:
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.

Roy A, Shi L, Chang A, Dong X, Fernandez A, Kraft JC, Li J, Le VQ, Winegar RV, Cherf GM, Slocum D, Poulson PD, Casper GE, Vallecillo-Zúniga ML, Valdoz JC, Miranda MC, Bai H, Kipnis Y, Olshefsky A, Priya T, Carter L, Ravichandran R, Chow CM, Johnson MR, Cheng S, Smith M, Overed-Sayer C, Finch DK, Lowe D, Bera AK, Matute-Bello G, Birkland TP, DiMaio F, Raghu G, Cochran JR, Stewart LJ, Campbell MG, Van Ry PM, Springer T, Baker D

Nat Commun 14 5660 (2023)

PMID: 37704610

Function and Biology Details

Biochemical function:

not assigned

Biological process:

not assigned

Cellular component:

not assigned

Structure analysis Details

Assembly composition:

monomeric (preferred)

Assembly name:

Integrin inhibitor (preferred)

PDBe Complex ID:

PDB-CPX-168436 (preferred)

Entry contents:

1 distinct polypeptide molecule

Macromolecule:

Integrin inhibitor Chains: A, B, C

Molecule details ›

Chains: A, B, C
Length: 75 amino acids
Theoretical weight: 8.55 KDa
Source organism: synthetic construct
Expression system: Escherichia coli