› 7l79

X-ray diffraction
2.83Å resolution

Crystal structure of broadly HIV-1-neutralizing antibody VRC40.01

Released:
DOI: 10.2210/pdb7l79/pdb
PDB 7l79 coloured by chain and viewed from the front.
PDB 7l79 coloured by chain and viewed from the side.
PDB 7l79 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of broadly HIV-1-neutralizing antibody
Zhou T
Cell Rep (2021)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heavy chain of VRC40.01 Chains: A, H
Molecule details ›
Chains: A, H
Length: 230 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain of VRC40.01 Chains: B, L
Molecule details ›
Chains: B, L
Length: 214 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand ZN 9 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 62.792Å b: 135.95Å c: 136.908Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.28
Expression system: Homo sapiens

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