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Structure of TRAF5 and TRAF6 RING Hetero dimer

X-ray diffraction
2.8Å resolution
PDB entry 7l3l coloured by chain, front view.
PDB entry 7l3l coloured by chain, side view.
PDB entry 7l3l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TNF receptor-associated factor 5 and TNF receptor-associated factor 6
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Multimeric state: hetero dimer
Accessible surface area: 14956.5 Å2
Buried surface area: 1419.52 Å2
Dissociation area: 660.1 Å2
Dissociation energy (ΔGdiss): -5.19 kcal/mol
Dissociation entropy (TΔSdiss): 11.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126297
Assembly 2
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Assembly Name: TNF receptor-associated factor 5 and TNF receptor-associated factor 6
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Multimeric state: hetero dimer
Accessible surface area: 14085.65 Å2
Buried surface area: 1394.9 Å2
Dissociation area: 645.6 Å2
Dissociation energy (ΔGdiss): -4.18 kcal/mol
Dissociation entropy (TΔSdiss): 11.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126297

Macromolecules

TNF receptor-associated factor 5
Chains: A, C
Length: 142 amino acids
Theoretical weight: 16.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00463 (Residues: 23-164; Coverage: 26%)
Gene names: RNF84, TRAF5
Pfam:
InterPro:
TNF receptor-associated factor 5 in PDB entry 7l3l, assembly 1, front view.
TNF receptor-associated factor 5 in PDB entry 7l3l, assembly 1, side view.
TNF receptor-associated factor 5 in PDB entry 7l3l, assembly 1, top view.
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TNF receptor-associated factor 6
Chains: B, D
Length: 107 amino acids
Theoretical weight: 12.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4K3 (Residues: 52-158; Coverage: 21%)
Gene names: RNF85, TRAF6
Pfam: Zinc finger, C3HC4 type (RING finger)
InterPro:
TNF receptor-associated factor 6 in PDB entry 7l3l, assembly 1, front view.
TNF receptor-associated factor 6 in PDB entry 7l3l, assembly 1, side view.
TNF receptor-associated factor 6 in PDB entry 7l3l, assembly 1, top view.
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