› 7kvx

X-ray diffraction
2.48Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 27.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 140-379; Coverage: 63%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand X5J 1 x X5J
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: C2
Unit cell:
a: 89.495Å b: 78.539Å c: 36.01Å
α: 90° β: 96.52° γ: 90°
R-values:
R R work R free
0.184 0.181 0.242
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Garland et al. (2022)